COVID-19 Staying Healthy with Exercise

When infected with flu-like viruses, each infected cell produces between 1,000 and 10,000 new viruses and the total number of flu viruses in your body can rise to trillions within a few days. In most people, the immune system wins this war of no small combat numbers within a week or so.

Exercise and other proactive health activity can help minimize the impact of a COVID-19 or any other viral infection. The immune system is amazing at targeting pathogens. For that to happen, immune cells must “find” the pathogen. Since we only have about 1.5 gallons of blood scattered with leukocytes and about 100,000 miles of blood vessels, we can help the random chance that the right immune cells will be in the right area so they can latch onto pathogens by improving blood flow / vasodilation through exercise. The same is true for lymphatic system fluids. Exercise improves those flow rates as well and leads to improved immunosurveillance.

With similar importance, higher blood and lymph flow from exercise while we are sick, even though we just want to lay in bed, can help remove septic materials when viral cells burst and/or deteriorate as they “birth” new virions; and improved flows may even help remove excess immune system cytokine action / pre-storm by pushing excess cytokines away from highly infected areas.

COVID appears to “predispose patients to thrombotic disease, both in the venous and arterial circulations, due to excessive inflammation, platelet activation, endothelial dysfunction, and stasis (areas of slow circulating blood)”. Common causes of endothelial dysfunction include diabetes, hypertension, smoking, and physical inactivity.

Rest is important; but too much laying in a bed, whether it be at home or in a hospital is probably counter to optimal recovery. This is probably intuitive except when we just really want to lay in bed. Conventional wisdom indicates that we feel better when we get exercise mixed with rest when sick compared to just laying there.

Could it be that the “power of suggestion” that we may need to be hospitalized is creating sedentary behavior during sickness that is unhelpful?

Either way, go get some exercise!

Also see Safety Information and Immunology and Hospitalized Patient Physical Therapy

Are we immune by chance? “The launch of an immune response can sometimes be predicted by mass action, because collisions have to take place between the pathogens and the cells of the immune system (e.g., Sykulev et al., 1995): the stronger the pathogen attack, the higher the immune reaction, on average. Nevertheless, how rapidly immune cells react will vary by host (Frank, 2002), partly because of variation in the rate at which immune cells patrol through the body (e.g., Lee et al., 2012).”

To clarify, this is not intended to create mystery or the idea that immunity is purely chance. It is intended to show that there are elements of probability in the functioning of the immune system and that increased blood and lymph flow increases those probabilities.

COVID-19 epidemiologists continue to research why clinical infection rates are lower in Japan and other Asian countries. It could be exercise that increases lymph flow such that the virus more rapidly contacts leukocytes in SLO germinal centers such that adaptive immune response is accelerated.

Cytokine storms and sepsis are a major contributor to COVID19 fatalities. This study of mice relates exercise and likelihood of sepsis in studies with mice.

Movement Matters – Pumping the Lymphatic System

“Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may predispose patients to thrombotic disease, both in the venous and arterial circulations, due to excessive inflammation, platelet activation, endothelial dysfunction, and stasis.”

Balance: Over-exercising and over-exercising immediately prior to infection / or during symptom development could be counter-productive, as one might intuitively guess. Is it possible that an anecdotal case study of a marathon runner COVID19 fatality was aggravated through extreme exercise sepsis? While this is not known, the negative effects of excessive exercise is explained in this article.

Going one step further, light exercise during early cytokine storm activity or pre-storm could be helpful. Take a walk when you are able. It could be too late during late-storm and sepsis, so it may be better to take that walk even when wanting to lay in bed all day.

Several general articles regarding health. COVID, and the great outdoors.

Perhaps it’s best to get that exercise outdoors where sunlight can generate vitamin D. Vitamin B is also helpful and tends to provide an energy boost. Vitamin C and multivitamins are helpful. Some articles favor megadoses, but meeting RDA levels is a safe recommendation. Essential oils such as peppermint and others found in mouthwash and breath fresheners can be soothing and especially helpful as preventative germicides.

Placing 1/16th of a zinc supplement (nibble off a small piece) and/or a few grains of salt in room temperature or slightly warm water will make the water much more pleasant to drink, which will enable you to remain well hydrated. The zinc also seems to have a throat soothing effect and may have some mild topical protective characteristics. Just a nibble and a few grains go a long way.

It has been well recognized that lying prone / stomach or side is healthier than lying on the back when lungs are being stressed.

Virus Life Cycles, Structure, Senses, Etc.

“Viruses can be released from the host cell by lysis, a process that kills the cell by bursting its membrane and cell wall if present. This is a feature of many bacterial and some animal viruses.”
“Budding is [another] method which viruses use to exit the cell. “Budding” through the cell envelope, in effect using the cell’s membrane for the virus itself is most effective for viruses that need an envelope in the first place. These include enveloped viruses such as HSV, SARS, or smallpox.”.
Influenza and SARS-CoV-2 are also enveloped viruses that are released through budding.

The genome of an RNA virus can be said to be either positive-sense, also known as a “plus-strand”, or negative-sense, also known as a “minus-strand”. In most cases, the terms “sense” and “strand” are used interchangeably, making terms such as “positive-strand” equivalent to “positive-sense”, and “plus-strand” equivalent to “plus-sense”.

The coronaviruses (CoVs) belong to the genus Coronavirus, the family Coronaviridae, and the order Nidovirales [1]. They are enveloped and have a non-segmented, single-stranded, positive-sense ribonucleic acid (ssRNA+) as their nuclear material. On electron microscopy, these viruses show a characteristic appearance that resembles a crown (corona in Latin means crown) due to the presence of club-shaped surface protein projections [2-3]. The CoVs are pleomorphic, measure between 80 and 160 nm in length, and have a small genome measuring 27-32 Kilobytes (KB) with a unique replication strategy

“Replication is very quick: after only 6 hours the first influenza viruses are shed from infected cells.”

So imagine multiplying by 1,000 to 10,000 every 6 hours. That’s what happens until the immune system engages the viruses and begins killing the viruses and the cells they have infected.

Also see Antibodies