{"id":3635,"date":"2021-04-05T14:09:47","date_gmt":"2021-04-05T21:09:47","guid":{"rendered":"https:\/\/reallycorrect.com\/ReallyCorrectWp1\/?page_id=3635"},"modified":"2021-11-12T00:07:23","modified_gmt":"2021-11-12T08:07:23","slug":"covid-19-vaccine-risks","status":"publish","type":"page","link":"https:\/\/reallycorrect.com\/ReallyCorrectWp1\/covid-19-vaccine-risks\/","title":{"rendered":"COVID-19 Vaccine Risks"},"content":{"rendered":"\n

Along with all aspects of life, there are risks related to viruses and the vaccines that are designed to protect us from those viruses. For a majority of the population, many studies strongly suggest that the benefits of vaccine far outweighs the risks of vaccine.<\/em><\/strong>

In the case where the risk of a virus is only slightly greater, equal-to, or lower than the risk of a vaccine for a given sub-population group, use of vaccines should be carefully evaluated.<\/em><\/strong> For example, with very young children who are at very low risk for a serious COVID-19 case, vaccination may not be of enough benefit to outweigh the risks. The initial December 2020 EUA’s for Pfizer and Moderna vaccines only addressed use in adults. With the very frail elderly, there is increased likelihood of adverse events associated with a strong immune response to a full-strength vaccine and very-near-term booster such as the 21 \/ 28 day Pfizer \/ Moderna boost schedules<\/a>. Many reports of significant immune response side-effects including fever, myalgia, headache, chills, etc. appear to be far more prevalent with dose 2<\/a>, while many report only injection site side-effects for dose 1.

Certain vaccines (e.g., adult tetanus and diphtheria toxoids [Td], pediatric diphtheria and tetanus toxoids [DT], tetanus toxoid) produce increased rates of local or systemic reactions in certain recipients when administered more frequently than recommended.<\/a> Interestingly, IgM (and IgG) unbound\u00a0antibody immune responses are generally peaking around the 15 to 30 day period past dose 1 vaccination<\/a>. Small numbers of anecdotal cases of death 2-3 weeks past dose 1<\/a> and immediately following dose 2<\/a> do seem to fit a plausible pattern of occurring during the peak immune response period suggesting that additional research of this phenomena and deferral of dose 2<\/a> and dose reduction may be prudent.

The generally high efficacy of the mRNA vaccines and significant numbers of adverse events may suggest that the dosages are not yet optimized and may be slightly high for some adults and children. Admittedly, the mRNA purification process leaves some undesirable mRNA elements within the resulting product<\/a> which could lead to very rare odd protein synthesis and unexpected immune response. While the vaccines have proven very favorable for reducing the impact of COVID-19 on many who are not in low-risk categories, improved research could lower the risk of the vaccine to those who are at very low risk of severe COVID-19. A September 2021 study stated: “Post-vaccination CAE rate was highest in young boys aged 12-15 following dose two. For boys 12-17 without medical comorbidities, the likelihood of post vaccination dose two CAE is 162.2 and 94.0\/million respectively. This incidence exceeds their expected 120-day COVID-19 hospitalization rate at both moderate (August 21, 2021 rates) and high COVID-19 hospitalization incidence. Further research into the severity and long-term sequelae of post-vaccination CAE is warranted.<\/a>“.

Since there are reasonable perceptions that mRNA vaccines have insufficient long-term safety data, and there are known concerns about mRNA manufacturing purification processes, and all vaccines have demonstrated adverse events and death in very healthy people at low-risk of severe COVID-19, optimal (lower) dosing options and boost timing, specific to physiology \/ risk \/ “weight” categories should be developed and available as options to the low-COVID-risk population to encourage vaccine acceptance and maximize safety ~Primum non nocere<\/em>. While it is not possible nor pragmatic to expect elimination of all vaccine risks, it likely that optimizations of dose and schedule could make the vaccine vs COVID risk enticing to the entire population, even those who have recovered from natural infection.

In November 2021, Moderna said their Covid vaccine has fewer breakthrough cases than Pfizer\u2019s, but higher myocarditis rates in young men<\/a>, further illustrating that there is a tradeoff between dose\/efficacy and adverse events such that current vaccine dosage may not provide a suitable benefit\/risk ratio for the entire population. Further, a senior NIH expert is pushing back on growing vaccine mandates: \u201cI think the way we are using the vaccines is wrong,\u201d he told Fauci. Matthew Memoli, a 16-year veteran at the NIH, who has reportedly applied for vaccine exemptions, favors vaccinations in vulnerable populations,<\/a> but not the entire population. Excessive boosting also adds risk.<\/a>

In mid-2021 there has been more discussion of intra-dermal vaccination in place of the currently prescribed intra-muscular vaccination method because the intra-dermal approach can achieve similar efficacy with only 1\/4 the dose<\/a>. Since the dosage is lower, it would be possible to vaccinate 4x more people in areas of the world with low access to vaccine. Additionally, a potential risk of the intra-muscular approach is that, if the administration misses muscle and it effectively becomes a intra-dermal delivery, the dosage could result in an effective dose 4x higher which could put the individual being vaccinated at higher risk of adverse events due to excessive immune response which can result in clotting<\/a> and other issues. This may also help explain some of the severe and terminal events surrounding dose 2 adverse events where IgM and general immune response is peaking. Thailand is exploring a lower dose intra-dermal approach.<\/a>

Vaccine dose\/schedule optimization opportunity exists for the very low risk population. For people in average health who have not already recovered well\/rapidly from natural infection<\/a>, the vaccine is likely much lower than the risk of COVID; although the the full strength vaccine does carry some risk. Using care to reduce exposure levels<\/a> can also reduce the risk of severe COVID. For a majority of the population, many studies strongly suggest that the benefits of vaccine far outweighs the risks of vaccine.<\/em><\/strong> This is particularly true when considering that “from 1999 \u20132000 through 2017 \u20132018, US\u00a0obesity prevalence\u00a0increased from 30.5% to 42.4%. During the same time, the\u00a0prevalence\u00a0of\u00a0severe\u00a0obesity increased from 4.7% to 9.2%<\/a>“. While vaccines are helpful, some additional ways to reduce risk of developing severe COVID includes healthy amounts of exercise<\/a> and reducing exposure potential<\/a>.<\/p>\n\n\n

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Balancing the Efficacy and Safety of Vaccines in the Elderly<\/div>
With advances in global health care, ageing populations are expected to grow worldwide throughout the 21[st] century. Increased lifespan is a testament to modern medical and social practices, but also presents a growing challenge to a system with limited …<\/div><\/div><\/div>\n\n
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Safety of High Doses of Influenza Vaccine and Effect on Antibody Responses in Elderly Persons<\/div>
Background Immune responses after influenza immunization are reduced in elderly individuals, the group at greatest risk for complications and death after influenza. Improved vaccines are needed to address this problem.Methods Ambulatory individuals 65 years and older (N\u00a0=\u00a0202) were…<\/div><\/div><\/div>\n\n
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Vaccination in the elderly: The challenge of immune changes with aging<\/div>
The unprecedented increase of life expectancy challenges society to protect the elderly from morbidity and mortality making vaccination a crucial mean\u2026<\/div><\/div><\/div>\n\n
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Ischaemic stroke and influenza A H1N1 vaccination: a case report<\/div>
We report a 75-year-old male patient who suffered posterior circulation ischaemia after influenza A\/H1N1 vaccination. Vaccination provokes a variable magnitude of inflammatory and immunological response that modifies the risk for ischaemic stroke. Whereas …<\/div><\/div><\/div>\n\n
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[Local reaction and neutralization test in smallpox vaccination after previous inoculation with MVA. Stickl\u2019s graduated vaccination (author\u2019s transl)] – PubMed<\/div>
Of 200 first inoculations and 8 revaccinations, the sera were examined for content of neutralizing vaccine antibodies 3 weeks after the MVA graduated inoculation. In spite of imponderables which affect the failure rate in the \u201cclinical trial\u201d, a positive result was obtained on first vaccination in 8\u2026<\/div><\/div><\/div>\n\n
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Half- vs Full-Dose Trivalent Inactivated Influenza Vaccine (2004-2005)<\/div>
Background Optimal public health strategies for managing influenza vaccine shortages are not yet defined. Our objective was to determine the effects of age, sex, and dose on the immunogenicity of intramuscular trivalent inactivated vaccine (TIV).Methods Healthy adults aged 18 to 64…<\/div><\/div><\/div>\n\n
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A Reduced-Dose Seasonal Trivalent Influenza Vaccine Is Safe and Immunogenic in Adult and Elderly Patients in a Randomized Controlled Trial<\/div>
With the recent pandemic of influenza A (H1N1) and vaccine shortages, there has been considerable interest in developing influenza vaccines with reduced doses, allowing for increased production capacity. Here we report a prospective, randomized, double-blind, …<\/div><\/div><\/div>\n\n
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What are the side effects of COVID-19 vaccines, and should you worry?<\/div>
In this feature, we look at the side effects of each of the 13 COVID-19 vaccines that have been authorized for use in at least one country.<\/div><\/div><\/div>\n\n
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Reactions and Adverse Events of the Pfizer-BioNTech COVID-19 Vaccine | CDC<\/div>
Information about reactions and adverse events reported by recipients of the Pfizer-BioNTech COVID-19 Vaccine<\/div><\/div><\/div>\n\n
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The Vaccine Adverse Event Reporting System (VAERS) Results<\/div>
Processing Request, please wait for results…<\/div><\/div><\/div>\n\n
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Waldenstrom\u2019s Disease: Symptoms, Diagnosis, and Treatments<\/div>
Waldenstrom\u2019s macroglobulinemia is rare type of non-Hodgkin lymphoma. This disease\u2019s symptoms, treatment, and outlook vary.<\/div><\/div><\/div>\n\n
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European Scientists Zero In On AstraZeneca Blood Clot Link<\/div>
A rare blood clotting condition has occurred in some people after receiving the AstraZeneca COVID-19 vaccine. If the new research is correct, it could mean that blood clots could be easily treated.<\/div><\/div><\/div>\n\n
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Platelet antibodies of the IgM class in immune thrombocytopenic purpura – PubMed<\/div>
The clinical course and response to therapy of patients with immune thrombocytopenic purpura (ITP) are not completely determined by the level of IgG present on the platelet surface. It is possible that antibodies of other immunoglobulin classes also play a role in platelet destruction in some of the\u2026<\/div><\/div><\/div>\n\n
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From Europe: 3,964 People Have Died from Adverse Drug Reactions for COVID-19 \u201cVaccines\u201d – 162,610 Injuries<\/div>
Thousands of Europeans have been injured and have died from taking the COVID-19 (China coronavirus) vaccine since it was first distributed to the public. A database maintained in Europe has an inventory of cases where people either died or were injured from the China coronavirus vaccines. The list i\u2026<\/div><\/div><\/div>\n\n